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How do Myxococcus cells direct their motility?

Laboratoire de Chimie Bacte´rienne, CNRS UMR 7283, Aix-Marseille Universite´ , Institut de Microbiologie de la Me´diterrane´ e, Marseille, France Professor Tam Mignot

Myxococcus cells can change their direction of movement by a process called a reversal where the poles exchange roles, allowing the bacteria to rapidly move in the opposite direction. Such rapid directional changes result from pole-to-pole switching of a central Ras-like small G-protein, MglA. Genetic control of these switches is at the heart of the Myxococcus multicellular lifestyle, swarming, prdation and fruiting body formation. How is MglA localization controlled dynamically? What signalling pathways control MglA localization? How is MglA regulating motility? How are those regulations affecting cell-cell cooperation in groups? For more information, see Mignot et al. (2005), Mauriello, Mouhamar et al. (2010), Zhang et al. (2010).