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ビデオ・アーカイブ

本領域の事業の一環として,細胞運動のビデオのオンラインライブラリーを作成します.細菌,真核生物,アーキア(古細菌),ウイルス,タンパク質, 合成ポリマー,など様々なものの動きを公開します.それぞれのビデオは,私たちが生物学的に掲載価値があるかどうかを判断,分類し,和文と英文で解説します.

ライブラリー作成のため,皆さまに,(1) 研究者によるご自身の研究対象の投稿,(2) スーパーサイエンスハイスクールや生物部の活動などで顕微鏡をのぞいていて見つけた微生物の投稿,などをお願いします.また,(3) 論文のビデオなどで当ライブラリーにリンクしてほしいもの,(4) 周囲に眠っている古いビデオ教材などでアーカイブ化の価値がありそうなもの,については領域事務局までご一報ください.

ライブラリーのアクセスランキングを下記のリンク先で公開しています。直近の3か月のアクセス数の多いビデオ10本を見ることができます。

また、ビデオ・アーカイブをより手軽に楽しんで頂くために、閲覧用スマートフォンアプリを開発いたしました。
以下からダウンロードできますので、是非ご覧下さい。

ビデオ・アーカイブの収録ビデオの利用に関しては下記へご連絡下さい。

伊藤政博 (masahiro.ito@toyo.jp)
東洋大学生命科学部生命科学科 教授
〒374-0193 群馬県邑楽郡板倉町泉野1-1-1
電話&FAX:0276-82-9202(研究室)、0276-82-9305(5105実験室)

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アクセスランキング

2014.09.30

原核生物
Three-dimensional reconstruction of vessel and fluorescent spirochetes

Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, and Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, Professor George Chaconas

Reconstruction and animation were performed on the z-series using the Amira 4.1 software package. The positions of the short-term interaction and stationary adhesion are indicated. A time-lapse microscopy series of two GFP-expressing B. burgdorferi in the capillary of the skin of a living C57 mouse is shown.

Plos Pathogen

2014.09.30

原核生物
Spinning disk confocal IMV of a transmigrating spirochete in the final stage of escape

種名:Borrelia burgdorferi
Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, and Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, Professor George Chaconas
 

Elapsed time is shown at the top right, and the scale at the bottom left. The time lapse was recorded at 0.94 fps and exported to video at 5 fps.

Plos Pathogen

2014.09.30

原核生物
Spinning disk confocal Intravital microscopy video of transmigrating fluorescent Borrelia burgdorferi

種名:Borrelia burgdorferi
Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, and Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, Professor George Chaconas
 

Bb repetitively translating forward and backward in the wall of a postcapillary venule. Elapsed time is shown at the top right, and the scale at the bottom left. The time lapse was recorded at 0.94 fps and exported to video at 5 fps. Blood flow direction is upward.

Plos Pathogen

2014.09.29

モデル(解説を含む)
A typical Brownian dynamics simulation

Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics and Howard Hughes Medical Institute, University of California–San Diego, La Jolla, California, United States of America, and Department of Pharmacology, University of California–San Diego, La Jolla, California, United States of America Professor Andrew McCammon

The simulation is initiated with kinesin and tubulin in random orientations and positions on the “initiation sphere,” where electrostatic energy contours are centrosymmetric. At large distances both proteins will undergo free diffusion leading to possible “escape.” At closer distances each protein will start to experience the electrostatic field of the other protein. Eventually, kinesin and tubulin will be close enough to favorably orient themselves with respect to their electrostatic fields. Note that in the simulations, both proteins are freely diffusing; here, for clarity, the camera tracks around the tubulin heterodimer.

Plos Biology

2014.09.29

モデル(解説を含む)
Consensus electrostatic potential map of the kinesin family

Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics and Howard Hughes Medical Institute, University of California–San Diego, La Jolla, California, United States of America, and Department of Pharmacology, University of California–San Diego, La Jolla, California, United States of America Professor Andrew McCammon

Illustrating the percentage of structures having a potential of the same sign at a particular region of space. Consensus potentials are displayed at the 80% level with a transparent surface and the 100% level with a solid surface.

Plos Biology

2014.09.29

モデル(解説を含む)
Surface mapped electrostatic potentials of the kinesin family

Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics and Howard Hughes Medical Institute, University of California–San Diego, La Jolla, California, United States of America, and Department of Pharmacology, University of California–San Diego, La Jolla, California, United States of America Professor Andrew McCammon

Values are expressed as a color spectrum ranging from +5 kT/e (blue) through 0 kT/e (white) to −5 kT/e (red). Panels correspond to front (toward the nucleotide binding site), rear, and mid-sliced views of the motor domain. Note, despite the overall diversity in charge distribution, the consistent positive patch (blue) on the rear face of the motor domain.

Plos Biology

2014.09.29

モデル(解説を含む)
Part 1: Introduction to Motor Proteins

UCSF Professor Ron Vale

Molecular motor proteins are fascinating enzymes that power much of the movement performed by living organisms. In the first part of this lecture, I will provide an overview of the motors that move along cytoskeletal tracks (kinesin and dynein which move along microtubules and myosin which moves along actin). The main focus of this lecture is on how motor proteins work. How does a nanoscale protein convert energy from ATP hydrolysis into unidirectional motion and force production? What tools do we have at our disposal to study them? The first part of the lecture will focus on these questions for kinesin (a microtubule-based motor) and myosin (an actin-based motor), since they have been the subject of extensive studies and good models for their mechanisms have emerged. I conclude by discussing the importance of understanding motor proteins for human disease, in particular illustrating a recent biotechnology effort from Cytokinetics, Inc. to develop drugs that activate cardiac myosins to improve cardiac contractility in patients suffering from heart failure. The first part of the lecture is directed to a general audience or a beginning graduate class. In the second part of this lecture, I will discuss our laboratories current work on the mechanism of movement by dynein, a motor protein about which we still know very little. This is a research story in progress, where some advances have been made. However, much remains to be done in order to understand how this motor works. The third (last) part of the lecture is on mitosis, the process by which chromosomes are aligned and then segregated during cell division. I will describe our efforts to find new proteins that are important for mitosis through a high throughput RNAi screen. I will discuss how we technically executed the screen and then focus on new proteins that are we discovered that are involved in generating the microtubules that compose the mitotic spindle. I also discuss the medical importance of studying mitosis, including the development of drugs targeted to mitotic motor proteins, which are currently undergoing testing in clinical trials.

2014.09.29

真核生物
Part 2: Single Molecule Approaches for Understanding Dynein

UCSF Professor Ron Vale

Molecular motor proteins are fascinating enzymes that power much of the movement performed by living organisms. In the first part of this lecture, I will provide an overview of the motors that move along cytoskeletal tracks (kinesin and dynein which move along microtubules and myosin which moves along actin). The main focus of this lecture is on how motor proteins work. How does a nanoscale protein convert energy from ATP hydrolysis into unidirectional motion and force production? What tools do we have at our disposal to study them? The first part of the lecture will focus on these questions for kinesin (a microtubule-based motor) and myosin (an actin-based motor), since they have been the subject of extensive studies and good models for their mechanisms have emerged. I conclude by discussing the importance of understanding motor proteins for human disease, in particular illustrating a recent biotechnology effort from Cytokinetics, Inc. to develop drugs that activate cardiac myosins to improve cardiac contractility in patients suffering from heart failure. The first part of the lecture is directed to a general audience or a beginning graduate class. In the second part of this lecture, I will discuss our laboratories current work on the mechanism of movement by dynein, a motor protein about which we still know very little. This is a research story in progress, where some advances have been made. However, much remains to be done in order to understand how this motor works. The third (last) part of the lecture is on mitosis, the process by which chromosomes are aligned and then segregated during cell division. I will describe our efforts to find new proteins that are important for mitosis through a high throughput RNAi screen. I will discuss how we technically executed the screen and then focus on new proteins that are we discovered that are involved in generating the microtubules that compose the mitotic spindle. I also discuss the medical importance of studying mitosis, including the development of drugs targeted to mitotic motor proteins, which are currently undergoing testing in clinical trials.

2014.09.29

モデル(解説を含む)
Part 3: Mining the Genome for Mitotic Treasures

UCSF Professor Ron Vale

Molecular motor proteins are fascinating enzymes that power much of the movement performed by living organisms. In the first part of this lecture, I will provide an overview of the motors that move along cytoskeletal tracks (kinesin and dynein which move along microtubules and myosin which moves along actin). The main focus of this lecture is on how motor proteins work. How does a nanoscale protein convert energy from ATP hydrolysis into unidirectional motion and force production? What tools do we have at our disposal to study them? The first part of the lecture will focus on these questions for kinesin (a microtubule-based motor) and myosin (an actin-based motor), since they have been the subject of extensive studies and good models for their mechanisms have emerged. I conclude by discussing the importance of understanding motor proteins for human disease, in particular illustrating a recent biotechnology effort from Cytokinetics, Inc. to develop drugs that activate cardiac myosins to improve cardiac contractility in patients suffering from heart failure. The first part of the lecture is directed to a general audience or a beginning graduate class. In the second part of this lecture, I will discuss our laboratories current work on the mechanism of movement by dynein, a motor protein about which we still know very little. This is a research story in progress, where some advances have been made. However, much remains to be done in order to understand how this motor works. The third (last) part of the lecture is on mitosis, the process by which chromosomes are aligned and then segregated during cell division. I will describe our efforts to find new proteins that are important for mitosis through a high throughput RNAi screen. I will discuss how we technically executed the screen and then focus on new proteins that are we discovered that are involved in generating the microtubules that compose the mitotic spindle. I also discuss the medical importance of studying mitosis, including the development of drugs targeted to mitotic motor proteins, which are currently undergoing testing in clinical trials.

2014.09.24

真核生物
60 minute time-lapse of Biomphalaria glabrata hemocytes spread

種名:Biomphalaria glabrata
Institute for the Environment, Brunel University, Uxbridge, London, United Kingdom Professor Adam E. Lynch

AVI file of image stack created in ImageJ, converted to 8-bit and stabilized.

Plos One

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