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ビデオ・アーカイブ

本領域の事業の一環として,細胞運動のビデオのオンラインライブラリーを作成します.細菌,真核生物,アーキア(古細菌),ウイルス,タンパク質, 合成ポリマー,など様々なものの動きを公開します.それぞれのビデオは,私たちが生物学的に掲載価値があるかどうかを判断,分類し,和文と英文で解説します.

ライブラリー作成のため,皆さまに,(1) 研究者によるご自身の研究対象の投稿,(2) スーパーサイエンスハイスクールや生物部の活動などで顕微鏡をのぞいていて見つけた微生物の投稿,などをお願いします.また,(3) 論文のビデオなどで当ライブラリーにリンクしてほしいもの,(4) 周囲に眠っている古いビデオ教材などでアーカイブ化の価値がありそうなもの,については領域事務局までご一報ください.

ライブラリーのアクセスランキングを下記のリンク先で公開しています。直近の3か月のアクセス数の多いビデオ10本を見ることができます。

また、ビデオ・アーカイブをより手軽に楽しんで頂くために、閲覧用スマートフォンアプリを開発いたしました。
以下からダウンロードできますので、是非ご覧下さい。

ビデオ・アーカイブの収録ビデオの利用に関しては下記へご連絡下さい。

伊藤政博 (masahiro.ito@toyo.jp)
東洋大学生命科学部生命科学科 教授
〒374-0193 群馬県邑楽郡板倉町泉野1-1-1
電話&FAX:0276-82-9202(研究室)、0276-82-9305(5105実験室)

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アクセスランキング

2014.09.29

真核生物
Part 2: Single Molecule Approaches for Understanding Dynein

UCSF Professor Ron Vale

Molecular motor proteins are fascinating enzymes that power much of the movement performed by living organisms. In the first part of this lecture, I will provide an overview of the motors that move along cytoskeletal tracks (kinesin and dynein which move along microtubules and myosin which moves along actin). The main focus of this lecture is on how motor proteins work. How does a nanoscale protein convert energy from ATP hydrolysis into unidirectional motion and force production? What tools do we have at our disposal to study them? The first part of the lecture will focus on these questions for kinesin (a microtubule-based motor) and myosin (an actin-based motor), since they have been the subject of extensive studies and good models for their mechanisms have emerged. I conclude by discussing the importance of understanding motor proteins for human disease, in particular illustrating a recent biotechnology effort from Cytokinetics, Inc. to develop drugs that activate cardiac myosins to improve cardiac contractility in patients suffering from heart failure. The first part of the lecture is directed to a general audience or a beginning graduate class. In the second part of this lecture, I will discuss our laboratories current work on the mechanism of movement by dynein, a motor protein about which we still know very little. This is a research story in progress, where some advances have been made. However, much remains to be done in order to understand how this motor works. The third (last) part of the lecture is on mitosis, the process by which chromosomes are aligned and then segregated during cell division. I will describe our efforts to find new proteins that are important for mitosis through a high throughput RNAi screen. I will discuss how we technically executed the screen and then focus on new proteins that are we discovered that are involved in generating the microtubules that compose the mitotic spindle. I also discuss the medical importance of studying mitosis, including the development of drugs targeted to mitotic motor proteins, which are currently undergoing testing in clinical trials.

2014.09.29

モデル(解説を含む)
Part 3: Mining the Genome for Mitotic Treasures

UCSF Professor Ron Vale

Molecular motor proteins are fascinating enzymes that power much of the movement performed by living organisms. In the first part of this lecture, I will provide an overview of the motors that move along cytoskeletal tracks (kinesin and dynein which move along microtubules and myosin which moves along actin). The main focus of this lecture is on how motor proteins work. How does a nanoscale protein convert energy from ATP hydrolysis into unidirectional motion and force production? What tools do we have at our disposal to study them? The first part of the lecture will focus on these questions for kinesin (a microtubule-based motor) and myosin (an actin-based motor), since they have been the subject of extensive studies and good models for their mechanisms have emerged. I conclude by discussing the importance of understanding motor proteins for human disease, in particular illustrating a recent biotechnology effort from Cytokinetics, Inc. to develop drugs that activate cardiac myosins to improve cardiac contractility in patients suffering from heart failure. The first part of the lecture is directed to a general audience or a beginning graduate class. In the second part of this lecture, I will discuss our laboratories current work on the mechanism of movement by dynein, a motor protein about which we still know very little. This is a research story in progress, where some advances have been made. However, much remains to be done in order to understand how this motor works. The third (last) part of the lecture is on mitosis, the process by which chromosomes are aligned and then segregated during cell division. I will describe our efforts to find new proteins that are important for mitosis through a high throughput RNAi screen. I will discuss how we technically executed the screen and then focus on new proteins that are we discovered that are involved in generating the microtubules that compose the mitotic spindle. I also discuss the medical importance of studying mitosis, including the development of drugs targeted to mitotic motor proteins, which are currently undergoing testing in clinical trials.

2014.09.24

真核生物
60 minute time-lapse of Biomphalaria glabrata hemocytes spread

種名:Biomphalaria glabrata
Institute for the Environment, Brunel University, Uxbridge, London, United Kingdom Professor Adam E. Lynch

AVI file of image stack created in ImageJ, converted to 8-bit and stabilized.

Plos One

2014.09.24

真核生物
10 hour scratch assay time-lapse of MDA-MB-231 cells, camera 1

Institute for the Environment, Brunel University, Uxbridge, London, United Kingdom Professor Adam E. Lynch

AVI file of image stack created in ImageJ, converted to 8-bit and stabilized.

Plos One

2014.09.23

モデル(解説を含む)
Actin filament assembly

Managing Editor, MBInfo (www.mechanobio.info) Professor Steven Wolf
Science Communications Facility, 
Mechanobiology Institute, National University of Singapore 
 

The actin network is made up of filamentous actin (F-actin). These filaments are highly dynamic in nature and comprise monomers of G-actin bound to either ATP (yellow) or ADP (blue). Assembly is powered by ATP hydrolysis and filament nucleation happens spontaneously in vitro. Polymerization: Addition of ATP-actin occurs at the barbed end, leading to filament elongation. Elongation will continue whilst the rate of elongation is greater than the loss of ADP-actin from the pointed end. Profilin preferentially binds to ATP-actin, inhibits nucleation and accelerates filament elongation in vivo. Depolymerization: When the dissociation rate of ADP-actin exceeds the rate of ATP-actin association, the filament shrinks. In vivo, this is aided by cofilin, which can severe filaments into short fragments and promote subunit loss from the pointed ends. Actin treadmilling occurs when the rate of association of ATP-actin and the rate of loss of ADP-actin are balanced. This video uploaded by permission from MBInfo: www.mechanobio.info; Mechanobiology Institute, National University of Singapore

MBInfo

2014.09.23

モデル(解説を含む)
Arp2/3 complex mediated actin nucleation

Managing Editor, MBInfo (www.mechanobio.info) Professor Steven Wolf
Science Communications Facility, 
Mechanobiology Institute, National University of Singapore 
 

Arp2/3 is a protein complex of seven subunits that is involved in the nucleation and assembly of branched actin filaments. The Arp2/3 complex is highly conserved and is found in most eukaryotes. Branched nucleation by the Arp2/3 complex requires a preformed actin filament and is regulated by proteins such as WASp and Cdc42 which are depicted in this animation using stylized schematic models. This video uploaded by permission from MBInfo: www.mechanobio.info; Mechanobiology Institute, National University of Singapore

MBInfo

2014.09.23

その他
サイエンスフロンティア21 (37)マイコプラズマ~滑走するバクテリア~

種名:Mycoplasma mobile
大阪市立大学 宮田真人

提供:科学技術振興機構(JST)

Unique centipede mechanism of Mycoplasma gliding.

2014.09.22

原核生物
Motility of Escherichia coli at 37°C

Archaea Centre, University of Regensburg, Regensburg, Germany Professor Reinhard Wirth

This movies shows motility of Escherichia coli at 37°C; the mean velocity is around 40 µm/s.

Appl. Env. Microbiol.

2014.09.22

原核生物
Motility of Pyrococcus furiosus at 90°C

種名: Pyrococcus furiosus
Archaea Centre, University of Regensburg, Regensburg, Germany Professor Reinhard Wirth

This movie shows motility of the archaeon Pyrococcus fusiosus at 90°C; the mean velocity is ca. 110 µm/s.

Appl. Env. Microbiol.

2014.09.22

原核生物
Motility of Methanocaldococcus villosus at 80°C

種名:Methanocaldococcus villosus
Archaea Centre, University of Regensburg, Regensburg, Germany Professor Reinhard Wirth

This movie shows motility of the archaeon Methanocaldococcus villosus at 80°C; the mean velocity is ca. 290 µm/s.

Appl. Env. Microbiol.

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